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CEP290 Polyclonal Antibody, Cat#CAC08307

$284.00

Cat#

CAC08307

Size: 100ug

Quantity:

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Species Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Application

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Estimated Turnaround Time

7-11 business days

Antibod Type

Primary Antibody

Isotype

IgG

Immunogen

Recombinant Human Centrosomal protein of 290 kDa protein (86-156AA)

Format

Unconjugated. Conjugated antibodies (Biotin, FITC and HRP) are available, please inquire.

Alternative Names

Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2), CEP290, BBS14 KIAA0373 NPHP6

UniProt

O15078

Purification

>95%, Protein G purified

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Conjugation service and the corresponding secondary antibody are available.

Technical Notes

Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May act as a gatekeeper to control entry of the BBSome complex to cilia (PubMed:25552655). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Activates ATF4-mediated transcription (PubMed:16682973).

Restriction

For Research Use Only. Not for use in diagnostic procedures. Not for human or animal drug or food use.

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