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HMGB2 Polyclonal Antibody, Cat#CAC09714

$284.00

Cat#

CAC09714

Size: 100ug

Quantity:

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Species Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Application

ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Estimated Turnaround Time

7-11 business days

Antibod Type

Primary Antibody

Isotype

IgG

Immunogen

Recombinant Human High mobility group protein B2 protein (43-185AA)

Format

Unconjugated. Conjugated antibodies (Biotin, FITC and HRP) are available, please inquire.

Alternative Names

High mobility group protein B2 (High mobility group protein 2) (HMG-2), HMGB2, HMG2

UniProt

P26583

Purification

>95%, Protein G purified

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Conjugation service and the corresponding secondary antibody are available.

Technical Notes

Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

Restriction

For Research Use Only. Not for use in diagnostic procedures. Not for human or animal drug or food use.

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