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TRPV4 Antibody, Cat#CAF18367

$279.00

Cat#

CAF18367

Size: 100ug

Quantity:

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Species Reactivity

Human, Mouse, Rat

Host

Rabbit

Clonality

Polyclonal

Application

WB, IF/ICC, ELISA

Estimated Turnaround Time

4-7 business days

Isotype

IgG

Immunogen

A synthesized peptide derived from human TRPV4

Conjugation

Unconjugated

Specificity

TRPV4 Antibody detects endogenous levels of total TRPV4

Gene ID

59341

Gene Name

TRPV4

Swiss-Prot

Q9HBA0

Purification

The antiserum was purified by peptide affinity chromatography.

Concentration

1mg/ml

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters (PubMed:16293632, PubMed:18826956, PubMed:18695040, PubMed:25256292, PubMed:20037586, PubMed:21964574). Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity). Acts as a regulator of intracellular Ca2+ in synoviocytes (PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329). Together with PKD2, forms mechano- and thermosensitive channels in cilium (PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity). Required for normal development and maintenance of bone and cartilage (PubMed:26249260).

Technical Notes

WB: 1:1000-3000 IF/ICC: 1:100-500

Restriction

For Research Use Only. Not for use in vitro diagnostic procedures, drug use, or for administration to humans or animals.

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