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KCNK1 Antibody, Cat#CAF15185

$279.00

Cat#

CAF15185

Size: 100ug

Quantity:

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Species Reactivity

Human, Rat

Host

Rabbit

Clonality

Polyclonal

Application

WB, IF/ICC, ELISA

Estimated Turnaround Time

4-7 business days

Isotype

IgG

Immunogen

A synthesized peptide

Conjugation

Unconjugated

Specificity

KCNK1 Antibody detects endogenous levels of total KCNK1

Gene ID

3775

Gene Name

KCNK1

Swiss-Prot

O00180

Purification

The antiserum was purified by peptide affinity chromatography.

Concentration

1mg/ml

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).

Technical Notes

WB 1:500~1:1000, IF/ICC: 1:100-1:500

Restriction

For Research Use Only. Not for use in vitro diagnostic procedures, drug use, or for administration to humans or animals.

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