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SYNCRIP Polyclonal Antibody, Cat#CAC09024

$284.00

Cat#

CAC09024
Ultra Sensitive IHC 

Size: 100ug

Quantity:

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Species Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Application

ELISA, WB, IHC; Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200

IHC Validation

Ultra Sensitive IHC Validation

Estimated Turnaround Time

7-11 business days

Antibod Type

Primary Antibody

Isotype

IgG

Immunogen

Recombinant Human Heterogeneous nuclear ribonucleoprotein Q protein (2-191AA)

Format

Unconjugated. Conjugated antibodies (Biotin, FITC and HRP) are available, please inquire.

Alternative Names

Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein), SYNCRIP, HNRPQ NSAP1

UniProt

O60506

Purification

>95%, Protein G purified

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Conjugation service and the corresponding secondary antibody are available.

Technical Notes

Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Restriction

For Research Use Only. Not for use in diagnostic procedures. Not for human or animal drug or food use.

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