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VPS29 Polyclonal Antibody, Cat#CAC08087

$284.00

Cat#

CAC08087

Size: 100ug

Quantity:

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Species Reactivity

Human

Host

Rabbit

Clonality

Polyclonal

Application

ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200

Estimated Turnaround Time

7-11 business days

Antibod Type

Primary Antibody

Isotype

IgG

Immunogen

Recombinant Human Vacuolar protein sorting-associated protein 29 protein (68-145AA)

Format

Unconjugated. Conjugated antibodies (Biotin, FITC and HRP) are available, please inquire.

Alternative Names

Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29), VPS29

UniProt

Q9UBQ0

Purification

>95%, Protein G purified

Storage

-20°C

Expiry Date

1 year

Shipping Condition

Ice packs

Comments

Conjugation service and the corresponding secondary antibody are available.

Technical Notes

Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (Probable). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514).

Restriction

For Research Use Only. Not for use in diagnostic procedures. Not for human or animal drug or food use.

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