In the modern era of bioscience, peptide synthesis comprises an enormous array of procedures and methods that allow researchers to prepare the materials, ranging from large proteins to meager peptides. Meanwhile, Bruce Merrifield's pioneering work strategically transformed peptide synthesis techniques and popularized the demanding and complex steps of purification associated with solution-phase synthesis.
In addition, Merrifield's SPPS allowed automation development and a comprehensive range of instrumentations now available. However, post-defining a specific synthesis strategy for peptide acid sequences, machines could automatically perform every synthesis step needed to develop numerous peptide samples. Meanwhile, some commercial enterprises also utilize protein production services, gene synthesis, and protein purification.