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Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 (MICAL2), partial, Cat#RPC24815

$274.00

Cat#

RPC24815

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Species

Homo sapiens (Human)

Source

Yeast

Tag Info

N-terminal 6xHis-tagged

Biological Activity

Not tested

Estimated Turnaround Time

7-11 business days

Gene Name

MICAL2

Alternative Names

Molecule interacting with CasL protein 2 ;MICAL-2

UniProt

O94851

Expression Region

1-495aa

AA Sequence

MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEH

Sequence Info

Partial

Theoretical MW

58.5kDa

Purity

> 90% as determined by SDS-PAGE.

Storage Buffer

Tris-based buffer,50% glycerol

Endotoxin Level

Not tested

Shipping Condition

Ice packs

Storage

Short term: -20°C; Long term: -80°C. Minimize freeze and thaw cycles.

Expiry Date

1 year

Research Area

Cell Biology

Restriction

For Research Use Only. Not for use in vitro diagnostic procedures, drug use, or for administration to humans or animals.

Relevance

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Function

Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H (2)O (2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum

Subcellular Location

Nucleus

Protein Families

Mical family

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